Severe rhabdomyolysis and myoglobinuria developed in a man taking
lovastatin about 2 months after
danazol was added. Another report describes a similar interaction with
simvastatin.
The US manufacturers of
lovastatin suggest that the dose should not exceed 20 mg daily in the presence of
danazol. Similarly the manufacturers of
simvastatin suggest that the dose should not exceed 10 mg daily in the presence of
danazol. It would seem prudent to remind patients of the
symptoms of myopathy if
danazol is given to a patient taking
lovastatin or
simvastatin, and tell them to report any unexplained muscle pain, tenderness or weakness.