DALFAMPRIDINE

(dal FAM pri deen) Brand: Ampyra

What is the most significant information I must know about dalfampridine?

• You must not use dalfampridine if you are allergic to it, or if you have temperate to severe kidney malady, if you have ever had a seizure (convulsions), or if you are also taking other multiple sclerosis drug called Fampridine.

• Till you take dalfampridine, speak your doctor if you have kidney disease.

• High doses of dalfampridine may magnify your risk of seizure. Do not take more than 2 tablets in a 24-hour period. Do not use a tablet that has been broken or crushed. A broken tablet can release too many of the drug at one time.

• Stop taking dalfampridine and call your doctor at once if you a seizure, pain or burning when you urinate, problems with your balance, numbness or tingly feeling, or a relapse of your MS symptoms.

What is dalfampridine?

• Dalfampridine is a potassium channel blocker.

• Dalfampridine is used to improve walking in patients with multiple sclerosis (MS).

• Dalfampridine may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking dalfampridine?

• You must not use dalfampridine if you are allergic to it, or if you have:

· temperate to severe kidney disease;

· if you have ever had a seizure (convulsions); or

· if you are also taking other MS drug called Fampridine (4-aminopyridine).

• To create certain you can safely take dalfampridine, speak your doctor if you have kidney disease.

• FDA pregnancy category C. It is not known whether dalfampridine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication..

• It is not known whether dalfampridine passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using dalfampridine.

• Do not give this medicine to anyone under 18 years old without the advice of a doctor.

How must I take dalfampridine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. High doses of dalfampridine may magnify your risk of seizure. Follow the directions on your prescription label.

• Dalfampridine is generally taken once each 12 hours. Follow your doctor's instructions.

• Do not take more than 2 tablets in a 24-hour period.

• Dalfampridine may be taken with or without food.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact. Do not dissolve the tablet in liquid. Breaking or dissolving the pill may reason too many of the drug to be released at one time.

• Do not use a dalfampridine tablet that has been accidentally crushed or broken. This can magnify your risk of having a seizure.

• To be certain this medicine is not causing deleterious effects, your kidney function may need to be checked with frequent blood trials. Visit your doctor regularly.

• Store at room temperature away from moisture and heat.

• Throw away any leftover medication after the expiration date on the label has passed.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose can reason confusion, problems with thinking or memory, tremors, sweating, or seizures.

What must I avoid while taking dalfampridine?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of dalfampridine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop taking dalfampridine and call your doctor at once if you have a serious side effect such as:

· seizure (convulsions);

· pain or burning when you urinate;

· problems with balance;

· numbness, burning pain, or tingly feeling;

· relapse or worsening of MS symptoms;

• Smaller serious side effects may include:

· headache, dizziness;

· sleep problems (insomnia);

· nausea, constipation, upset stomach;

· weakness;

· stuffy nose, sinus pain, sore throat; or

· back pain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect dalfampridine?

• There may be another drugs that can interact with dalfampridine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about dalfampridine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.