Cyclosporine (Sandimmune, Neoral, SangCya); Immunosuppressant Agent;
Sandimmune
Cap: 25, 50, 100 mg
Inj: 50 mg/mL [5 mL]
Soln: 100 mg/mL
SangCya
Soln: 100 mg/mL
Neoral (microemulsion)
Cap: 25, 100 mg
Soln: 100 mg/mL;
IV: 5-6 mg/kg administered 4-12h prior to organ transplantation, followed by 2-10 mg/kg/day q8-24h.
Oral: 14-18 mg/kg administered 4-12h prior to organ transplantation, followed by 5-15 mg/kg/day q12-24h. Taper dosage to 3-10 mg/kg/day q12-24h.
Monitor
serum levels; therapeutic range depends on which organ transplanted and which assay used. An initial 1:1 conversion from
Sandimmune/SangCya to Neoral is recommended, but lower doses of the microemulsion dosage form may be required.