| CYCLIZINE HYDROCHLORIDE
Marezine Lactate, Marzine
Classifications: antihistamine (h1-receptor antagonist); antivertigo agent; antiemetic; Therapeutic:antivertigo; antiemetic; antihistamine
Pregnancy Category: B
50 mg tablets; 50 mg/mL injection
Piperazine antihistamine (H1-receptor antagonist) that exhibits CNS depression and anticholinergic, antispasmodic, local anesthetic, and antihistaminic
activity. Has prominent depressant action on labyrinthine excitability and on conduction in vestibular-cerebellar pathways.
Produces marked antimotion and antiemetic effects.
Chiefly for prevention and treatment of motion sickness and postoperative nausea and vomiting.
Increased intraocular pressure; asthma, closed-angle glaucoma; children <6 y.
Narrow-angle glaucoma; prostatic hypertrophy; elderly; obstructive disease of GU or GI tracts; postoperative patients; pregnancy
(category B), lactation.
Route & Dosage
Adult: PO 50 mg 30 min before travel, then q46h prn (max: 200 mg/d) IM 50 mg q46h prn
Child: PO 612 y, 25 mg q46h prn (max: 75 mg/d) IM 612 y, 1 mg/kg t.i.d. prn (max: 75 mg/d)
Adult: IM 50 mg 1530 min before end of operation, may repeat q46h (t.i.d.) prn during first few days after surgery
- Give dose 30 min prior to any activity likely to cause motion sickness.
- Aspirate needle carefully before injecting IM. Anaphylactic reactions following inadvertent IV injection have been reported.
- For prophylaxis of postoperative nausea and vomiting, drug usually prescribed with preoperative medication or is administered
2030 min before expected termination of surgery.
- Store tablets in tight, light-resistant container at 15°30° C (59°86° F) unless otherwise
directed. Store parenteral form in a cold place at 5°10° C (41°50° F). When parenteral solution
is stored at room temperature for prolonged periods, it may become slightly yellow, but this does not indicate loss of potency.
Adverse Effects (≥1%)CV:
Hypotension, palpitation, tachycardia. GI:
Anorexia, nausea, vomiting, diarrhea, or constipation
, cholestatic jaundice
. CNS: Drowsiness,
excitement, euphoria, auditory and visual hallucinations, hyperexcitability alternating with drowsiness, convulsions, respiratory paralysis
Urticaria, rash. Special Senses: Dry mouth,
nose, and throat; blurred vision, diplopia; tinnitus. Other:
Pain at IM injection site.
Diagnostic Test Interference
Because cyclizine is an antihistamine, inform patient that skin testing procedures should not be scheduled for about 4 d after drug is discontinued or false-negative reactions may result.
Interactions Drug: Alcohol, barbiturates
, cns depressants
, and anxiolytics
) may compound effects of cyclizine.
46 h. Metabolism:
Assessment & Drug Effects
- Monitor post-operative patient's vital signs closely, as cyclizine can cause hypotension.
- Monitor for and report signs of CNS stimulation (e.g., hyperexcitability, euphoria). Dose reduction or discontinuation of
drug may be indicated.
Patient & Family Education
- Take cyclizine with food or a glass of milk or water to minimize GI irritation.
- Do not drive a car or engage in other potentially hazardous activities until reaction to the drug is known. Adverse effects
include drowsiness and dizziness.
- Alcohol, barbiturates, narcotic analgesic, and other CNS depressants may compound sedative action.