CORTICOSTEROIDS AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

Only small increases or decreases in anticoagulation normally occur when low to moderate doses of corticosteroids are given with oral anticoagulants. However, some patients have shown very marked prothrombin time increases when given high-dose corticosteroids.
Monitor the anticoagulant effect if high-dose corticosteroids are started or stopped in patients taking oral anticoagulants.