Ciprofloxacin, moxifloxacin and
ofloxacin have been shown not to affect the
pharmacokinetics of the combined oral
contraceptives in controlled studies. Contra- ceptive failure does not appear to have been reported, and ovarian suppression is not affected.
It is possible that the anecdotal cases of contraceptive failure with antibacterials are indistinguishable from the normal accepted failure rate and no special precautions are required. However, some specialists recommend that additional
contraceptives, such as condoms, should be used for short courses of antibacterials. For guidance on the use of antibacterials with
contraceptives, see contracep- tives.