CONTRACEPTIVES AND CO-TRIMOXAZOLE

Co-trimoxazole modestly increases ethinylestradiol levels. However, there are about 15 anecdotal cases on record of contraceptive failure attributed to co-trimoxazole. There are also isolated cases of contraceptive failure attributed to various sulphonamides, and trimethoprim.
Not established. The pharmacokinetic and pharmacodynamic evidence indicates that co-trimoxazole is not likely to reduce the effectiveness of combined hormonal contraceptives. Although there are a number of reports of contraceptive failure attributed to co-trimoxazole, these are anecdotal and unconfirmed. It is possible that these cases are coincidental, and fit within the normal failure rate of combined hormonal contraceptives. It has been said that it is almost certain that co-trimoxazole does not interact with combined hormonal contraceptives.
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