(KOM ple ment C1 ES ter ase in HIB it or) Brand: Berinert, Cinryze
• You must not use this medicine if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.
• Till you receive complement C1 esterase inhibitor, speak your doctor if you have a history of stroke or blood clot.
• Do not give this medicine to a baby without medical advice.
• You may be shown how to use Cinryze in an IV at house. This medicine comes with patient instructions for safety and effective use. Follow all directions carefully. Ask your doctor or pharmacist if you have any questions.
• Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and another items used to inject the medication. Be certain you understand how to properly mix and store the medicine.
• Stop your IV infusion and get abnormal medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficult breathing; feeling like you might pass out; or swelling of your person, lips, tongue, or throat.
• Another serious side effects may include sudden numbness or weakness, chest pain, confusion, pain or swelling, and problems with vision, speech, or balance.
• Complement C1 esterase inhibitor is made from human plasma (part of the blood) which may contain viruses and another infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a little possibility it could transmit malady. Conversation with your doctor about the risks and benefits of using this medication.
• Complement C1 esterase inhibitor is a man-made form of a protein that occurs naturally in the blood stream and helps control inflammation in the body. In people with hereditary angioedema, complement C1 esterase inhibitor does not function properly or occurs in low levels.
• Complement C1 esterase inhibitor is used in people with hereditary angioedema. The Berinert brand of this medicine is used to treat attacks of angioedema. The Cinryze brand is used to prevent attacks of angioedema.
• Complement C1 esterase inhibitor may also be used for purposes not listed in this medicine guide.
• You must not use this medicine if have ever had a life-threatening allergic reaction to complement C1 esterase inhibitor.
• To create certain you can safely use complement C1 esterase inhibitor, speak your doctor if you have a history of stroke or blood clot.
• FDA pregnancy category C. It is not known whether complement C1 esterase inhibitor will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• It is not known whether complement C1 esterase inhibitor passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.
• Complement C1 esterase inhibitor is made from human plasma (part of the blood) which may contain viruses and another infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a little possibility it could transmit malady. Conversation with your doctor about the risks and benefits of using this medication.
• Do not give this medicine to a baby without medical advice.
• Use exactly as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.
• Complement C1 esterase inhibitor is injected into a vein through an IV. A healthcare provider will give you a Berinert injection in a clinic or hospital setting. You may be shown how to use Cinryze in an IV at house. Do not self-inject this medication if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and another items used to inject the medicine.
• This medicine comes with patient instructions for safety and effective use. Ask your doctor or pharmacist if you have any questions.
• Complement C1 esterase inhibitor is a powder medication that should be mixed with a liquid (diluent) till using it. If you are using Cinryze house, you will need to use two vials of Cinryze to create up a single doze. Follow all directions carefully. Be certain you understand how to properly mix and store the medication.
• Gently swirl but do not shake the mixed medication or you may ruin it. Prepare your doze only when you are ready to give yourself an injection.
• Mixed Berinert must be clear and colorless. Mixed Cinryze must be clear or slightly blue in color. Do not use the mixed medication if it has changed colors, is cloudy, or has any particles in it. Call your doctor for a new prescription.
• Cinryze is generally given each 3 or 4 days to prevent angioedema attacks. An IV infusion takes about 10 minutes to complete.
• Complement C1 esterase inhibitor contains no preservative. Once you have pierced the rubber top of a vial with a needle, you should use that vial right away or throw it away.
• Every single use vial (bottle) of this medication is for one use only. Throw away after one use, even if there is still some medication left in it after injecting your dose.
• Use every disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Hold this container out of the reach of children and pets.
• Store the unmixed dry powder in a refrigerator or in a dark cold seat. Hold the medication protected from easy and do not let it to freeze. Throw away any unused vial after the expiration date on the label has passed.
• After mixing Berinert with the diluent, use it right away or store the mixture at room temperature and use it within 8 hours.
• After mixing Cinryze with the diluent, use it right away or store the mixture at room temperature and use it within 3 hours.
• Use the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not use extra medication to create up the missed dose.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Overdose symptoms may include sudden headache, numbness, weakness, or problems with your speech, vision, or balance.
• Follow your doctor's instructions about any restrictions on food, beverages, or activity.
• Stop your IV infusion and get abnormal medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficult breathing; feeling like you might pass out; or swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have any another serious side effect, such as:
· new or worsening pain;
· sudden numbness or weakness, especially on one side of the body;
· sudden severe headache, confusion, problems with vision, speech, or balance;
· stomach pain or swelling;
· chest pain, sudden cough, rapid breathing, quick heart course; or
· pain, swelling, warmth, or redness in one or both legs.
• Smaller serious side effects may include:
· nausea, vomiting, stomach pain;
· altered sense of taste;
· cool symptoms such as stuffy nose, sneezing, sore throat;
· mild itching or rash; or
· mild headache.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• There may be another drugs that can interact with this medicine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about complement C1 esterase inhibitor.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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