The manufacturers report that the concurrent use of
colestyramine reduced the absorption of
raloxifene by about 60%, due to an interruption in enterohepatic cycling.
Separating
administration is unlikely to be effective as the interaction is via enterohepatic circulation. It is recommended that these two drugs should not be
Colestyramine and related drugs
used concurrently. Other drugs, such as colestipol, are expected to interact similarly.