Three case reports describe myopathy or rhabdomyolysis in patients given colchicine and fluvastatin, pravastatin or simvastatin. It seems possible that this reaction could occur with colchicine and any statin.
Although this interaction is rare it is serious. Given the evidence available it seems likely to occur with all statins, although this has not been clearly demonstrated. All patients taking statins should be warned about the symptoms of myopathy and told to report muscle pain or weakness. It would be prudent to reinforce this advice if they are given colchicine.
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