The
SSRIs may increase the risk of upper
gastrointestinal bleeding and the risk appears to be further increased by concurrent
clopidogrel.
The manufacturers of the
SSRIs warn that patients should be cautioned about the concurrent use of antiplatelet drugs. Consideration should be given to the prescribing of gastroprotective drugs (such as proton pump inhibitors) in those at high risk of
gastrointestinal bleeding, such as elderly patients or those with a history of
gastrointestinal bleeding.