The risk of faecal blood loss,
gastrointestinal haemorrhage and other bleeding is increased by concurrent use of
clopidogrel with
naproxen and
celecoxib.
The manufacturers advise caution if
NSAIDs and
clopidogrel are given together. Consider giving additional
gastrointestinal prophylaxis such as a proton pump inhibitor in patients at risk of
gastrointestinal ulceration and bleeding.