CLONIDINE AND TRICYCLICS

The tricyclic antidepressants, clomipramine, desipramine and imipramine reduce or abolish the antihypertensive effects of clonidine. Other tricyclics are expected to behave similarly. A hypertensive crisis developed when a woman taking clonidine was given imipramine.
This interaction is not seen in all patients. Avoid concurrent use unless the effects on blood pressure can be monitored. Increasing the dosage of clonidine seems to be an effective way of managing this interaction.