Limited evidence suggests that the
control of Parkinson's disease with
levodopa may be impaired by
clonidine.
Be alert for a reduction in the
control of the Parkinson's disease during concurrent use. The effects of this interaction appear to be reduced if antimuscarinic drugs are also being used. Be aware that, as with all
antihypertensives, additive hypotensive effects may occur with levodopa, see
antihypertensives.