Ciprofloxacin may decrease the clearance (and therefore increase the levels) of cinacalcet, by inhibiting its
metabolism by CYP1A2.
It may be prudent to monitor parathyroid hormone and
serum calcium more frequently if ciprofloxacin is started or stopped. Note that other
quinolones may also inhibit CYP1A2, see
quinolones, and may therefore also interact.