Case reports describe decreased
warfarin or acenocoumarol effects, which were attributed to an interaction with
ciclosporin.
Warfarin and acenocoumarol have decreased
ciclosporin levels in isolated cases, and a further report describes a rise in
serum ciclosporin levels when an unnamed anticoagulant was given.
Information is limited. In patients taking an anticoagulant with ciclosporin, it may be prudent to consider an increase in the frequency of the standard monitoring of both drugs.