CHORIONIC GONADOTROPIN (go-nad'oh-troe-pin) Pregnyl Classifications: hormone; human chorionic gonadotropin (hcg); Therapeutic:hcg hormone Pregnancy Category: X |
10,000 unit vial
Human chorionic gonadotropin (HCG) is a polypeptide hormone produced by the placenta and extracted from urine during first trimester of pregnancy. Actions nearly identical to those of pituitary luteinizing hormone (LH). Promotes production of gonadal steroid hormones by stimulating interstitial cells of the testes to produce androgen, and the corpus luteum of the ovary to produce progesterone.
Administration of HCG to women of childbearing age with normal functioning ovaries causes maturation of the ovarian follicle and triggers ovulation. When given during normal pregnancy, it maintains corpus luteum after LH decreases, supports continuing secretion of estrogen and progesterone, and prevents ovulation.
Prepubertal cryptorchidism not due to anatomic obstruction and male hypogonadism secondary to pituitary deficiency. Also used in conjunction with menotropins to induce ovulation and pregnancy in infertile women in whom the cause of anovulation is secondary; ovulation usually occurs within 18 h. To stimulate spermatogenesis in males with hypogonadism.
Corpus luteum dysfunction.
Known hypersensitivity to HCG, hypogonadism of testicular origin, hamster protein hypersensitivity; hypertrophy or tumor of pituitary, prostatic carcinoma or other androgen-dependent neoplasms, precocious puberty; ovarian failure; dysfunctional uterine bleeding; adrenal insufficiency; uncontrolled thyroid disease; children <4 y; neonates; pregnancy (category X).
Epilepsy, migraine, asthma, cardiac or renal disease; endometriosis; thrombophlebitis; lactation.
Prepubertal Cryptorchidism Child: IM 4000 units 3 times/wk for 3 wk, or 5000 units q.o.d. for 4 doses, or 5001000 units 3 times/wk for 46 wk Hypogonadotropic Hypogonadism Adult: IM 5001000 units 3 times/wk for 3 wk, then 2 times/wk for 3 wk or 4000 units 3 times/wk for 69 mo followed by 2000 units 3 times/wk for 3 mo Stimulation of Spermatogenesis Adult: IM 5000 units 3 times/wk until normal testosterone levels are achieved (46 mo), then 2000 units 2 times/wk with menotropins for 4 mo Induction of Ovulation Adult: IM 5001000 units 1 d following last dose of menotropins |
Pregnancy tests: Possibility of false results.
Assessment & Drug Effects
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