| CHOLINE MAGNESIUM TRISALICYLATE
(cho'leen mag-ne'si-um tri-sal'i-ci-late)
Classifications: analgesic (salicylate), nonsteroidal antiinflammatory drug (nsaid); antipyretic; Therapeutic:nsaid, analgesic (salicylate)
Pregnancy Category: C first and second trimester; D third trimester
500 mg, 750 mg, 1000 mg tablets; 500 mg/5 mL liquid
Choline magnesium trisalicylate is a nonsteroidal, antiinflammatory preparation combining choline salicylate and magnesium
salicylate. Mode of action is by inhibiting prostaglandin synthesis by reversibly inhibiting cyclooxygenase (both COX-1 and
COX-2), resulting in its antiinflammatory properties as well as its analgesic property.
Has antiinflammatory, analgesic, and antipyretic action. Platelet aggregation is not affected.
Osteoarthritis, rheumatoid arthritis, and other arthrides. Preferable to aspirin for patients with GI bleeding.
Hypersensitivity to nonacetylated salicylates; children <6 y; children and teenagers with chickenpox, influenza, or flu
symptoms because of the potential for Reye's syndrome; coagulopathy, anticoagulant therapy, G6PD deficiency; pregnancy (category
C first and second trimester and category D in third trimester); contraindicated in late pregnancy, near term, or in labor
Chronic renal and hepatic failure, history of GI disease, peptic ulcer; patients on coumadin or heparin, anemia; hypovolemic
states; lactation; older adults.
Route & Dosage
Adult: PO 1.52.5 g/d in 13 divided doses (max: 4.5 g/d)
Mild to Moderate Pain, Fever
Adult: PO 23 g/d in 2 divided doses
Child: PO 3060 mg/kg/d in 34 divided doses
- Give with food to reduce gastric upset. Do not give with antacids.
- Store at 59°86° F (15°30° C).
Adverse Effects (≥1%)GI:
Vomiting, diarrhea. CNS:
Headache, vertigo, confusion, drowsiness. Special Senses:
InteractionsDrug: Aminosalicylic acid
increases risk of salicylate toxicity; ammonium chloride
and other acidifying agents
decrease its renal elimination, increasing risk of salicylate toxicity; anticoagulants
increase risk of bleeding; carbonic anhydrase inhibitors
enhance salicylate toxicity; corticosteroids
compound ulcerogenic effects; increases methotrexate
toxicity; low doses of salicylates may antagonize uricosuric effects of probenecid, sulfinpyrazone.
Readily absorbed from small intestine. Onset:
30 min. Peak:
13 h. Metabolism:
In liver. Elimination:
In urine. Half-Life:
Assessment & Drug Effects
- As with other NSAIDs, the antipyretic and antiinflammatory effects may mask usual S&S of infection or other diseases.
- Assess for GI discomfort; nausea, gastric irritation, indigestion, diarrhea, and constipation are frequent complaints.
- Monitor for S&S of bleeding. Closely monitor PT if used concurrently with warfarin.
Patient & Family Education
- Avoid taking aspirin, NSAIDs, or acetaminophen concurrently with drug.
- Avoid dangerous activities until reaction to drug is determined, due to possible CNS effects (e.g., vertigo, drowsiness).
- Report tinnitus or persistent gastric irritation and epigastric pain.
- Report any unexplained bruising or bleeding to physician.
- Hypoglycemic effects may be enhanced for those with type 2 diabetes taking an oral hypoglycemic agent (OHA).
- Do not give to children or teenagers with chickenpox, influenza, or flu symptoms because of association with Reye's syndrome.