The concurrent use of
chloroquine and
penicillamine may result in increased
toxicity, possibly as a result of increased
penicillamine levels.
If problems occur consider this drug interaction as a possible cause. Note that chloroquine,
hydroxychloroquine and
penicillamine are associated with serious haematological adverse effects, and therefore the US manufacturers suggest that the use of
penicillamine with either of these drugs should be avoided.