Ranitidine and
famotidine reduce the bioavailability of
cefpodoxime proxetil. Ranitidine (with sodium bicarbonate) reduces the bioavailability of cefuroxime axetil.
In most cases the interactions between the
cephalosporins and
H2-receptor antagonists are not clinically significant. The
clinical importance of the interaction with
cefpodoxime has not been studied, but the manufacturer recommends that it should be given at least 2 hours before
H2-receptor antagonists. As it is thought that a change in gastric pH is responsible for this interaction it would seem likely that all
H2-receptor antagonists will interact similarly. As long as cefuroxime is taken with food (as is recommended), any interaction is minimal.