| CEFDITOREN PIVOXIL
Classifications: antibiotic; third-generation cephalosporin; Therapeutic: antibiotic; cephalosporin
Prototype: Cefotaxime sodium
Pregnancy Category: B
200 mg tablets
Semisynthetic cephalosporin. Bactericidal activity results from the inhibition of cell wall synthesis through an affinity
for penicillin-binding proteins (PBPs). Stable in the presence of a variety of bacterial beta-lactamase enzymes, including
penicillinases and some cephalosporinases.
Antibacterial activity is effective against both aerobic gram-positive and aerobic gram-negative bacteria.
Acute exacerbation of bacterial chronic bronchitis, pharyngitis, tonsillitis, uncomplicated skin and skin-structure infections.
Known allergy to cephalosporins or any of the components of cefditoren; carnitine deficiency; milk protein hypersensitivity.
History of hypersensitivity to penicillin or other drugs; renal or hepatic impairment; poor nutritional status; coagulopathy;
diabetes mellitus; colitis, GI disease; older adults; concurrent anticoagulant therapy; pregnancy (category B), lactation.
Safety and efficacy in children <12 y are not established.
Route & Dosage
Adult: PO 400 mg b.i.d. x 10 d
Pharyngitis, Tonsillitis, Skin Infections
Adult: PO 200 mg b.i.d. x 10 d
Clcr 3049 mL/min: 200 mg b.i.d.; <30 mL/min: 200 mg q.d.
- Give with food to enhance absorption.
- Do not give within 2 h of an antacid or H2-receptor antagonist (such as cimetidine).
- Verify dose for patients with renal insufficiency. Manufacturer recommends doses not to exceed 200 mg b.i.d. for patients
with creatinine clearance of 3049 mL/min and doses not to exceed 200 mg q.d. for patients with creatinine clearance
of <30 mL/min.
- Store at 15°30° C (58°86° F). Protect from light and moisture.
Adverse Effects (≥1%) GI: Diarrhea,
nausea, abdominal pain, dyspepsia, vomiting. Hematologic:
Anemia, leukocytosis. CNS:
Vaginal moniliasis, hematuria.
, h2-receptor antagonists
may decrease absorption; probenecid
will decrease elimination.
14% reaches systemic circulation. Distribution:
88% protein bound, distributes into blister fluid, tonsils. Metabolism:
Primarily in urine. Half-Life:
Assessment & Drug Effects
- Obtain history of hypersensitivity to cephalosporins, penicillins, and other drug allergies.
- Lab tests: Baseline C&S tests recommended prior to and periodically during therapy. Initiate drug pending results. Baseline
and periodic studies of kidney function; frequent PT determinations in patients at risk for increased prothrombin time;
as indicated, Hct & Hgb, CBC with differential, urinalysis, serum electrolytes, and liver enzymes.
- Monitor for manifestations of drug hypersensitivity (see Appendix F). Withhold drug and report promptly to physician if they
- Monitor for and report promptly manifestations of superinfection (see Appendix F), especially diarrhea. Diarrhea may indicate
a change in intestinal flora and development of enterocolitis. If it persists, interruption of therapy may be necessary.
- Monitor for and report immediately signs of seizure activity or loss of seizure control.
Patient & Family Education
- Do not take within 2 h of antacids or other drugs used to reduce stomach acids.
- Discontinue drug and report to physician signs of an allergic reaction (e.g., rash, urticaria, pruritus, fever).
- Report promptly S&S of superinfection (see Appendix F), especially unexplained diarrhea. Antibiotic-associated colitis is
a superinfection that may occur in 49 d or as long as 6 wk after drug is discontinued.
- Use daily yogurt or buttermilk (if allowed) as a prophylactic against intestinal superinfections.