Caspofungin decreases trough
tacrolimus levels by 26%.
Tacrolimus does not affect the
pharmacokinetics of
caspofungin.
Tacrolimus levels and/or effects (e.g. on
renal function) should be monitored as a matter of routine, but it is advisable to increase monitoring if
caspofungin is started or stopped, and adjust the dose of
tacrolimus if required.