| CARBENICILLIN INDANYL SODIUM
Geocillin, Geopen Oral
Classifications: antibiotic; antipseudomonal penicillin; Therapeutic: antibiotic; penicillin
Pregnancy Category: B
382 mg tablets
Broad-spectrum, semisynthetic penicillin that rapidly hydrolyzes to carbenicillin in body.
Like carbenicillin disodium, it is bactericidal and penicillinase sensitive and has similar antimicrobial activity but achieves
lower blood concentrations than parent compound.
Mainly in the treatment of prostatitis and acute and chronic infections of upper and lower urinary tract.
Hypersensitivity to penicillins; coagulation disorders. Safe use in children not established.
History of or suspected atopy or allergies; history of allergy to cephalosporins or carbapenem; colitis; diabetes mellitus;
lactation; impaired renal and hepatic function; patients on sodium restriction; pregnancy (category B).
Route & Dosage
|Urinary Tract Infections
Adult: PO 382764 mg q6h for 10 d, continue for 24 wk for prostatitis
- Give with a full glass (240 mL) of water on an empty stomach (either 1 h before or 2 h after meals) to attain maximum therapeutic
drug levels in urine. Consult physician.
- Protect tablets from moisture.
Adverse Effects (≥1%)Body as a Whole:
Hypersensitivity (rash, fever, urticaria, eosinophilia, pruritus, anaphylaxis
), superinfections, especially of vagina. GI: Nausea,
vomiting, heartburn; diarrhea,
abdominal cramps, flatulence, unpleasant aftertaste, dry mouth. Hematologic: Neutropenia
, hemolytic anemia,
Incompletely from GI tract. Peak:
0.51 h. Distribution:
Very low systemic concentrations; crosses placenta; distributed into breast milk. Elimination:
8099% unchanged in urine within 24 h. Half-Life:
Assessment & Drug Effects
- Lab tests: Perform culture and sensitivity tests prior to and at regular intervals throughout therapy. Therapy may be initiated
pending test results. Evaluate renal, hepatic, and hematopoietic systems at regular intervals during prolonged therapy.
Patients with creatinine clearance of less than 10 mL/min (normal: 105130 mL/min) will not attain therapeutic urine
- Inquire carefully concerning patient's previous exposure and sensitivity to penicillin and cephalosporins and other allergic
reactions of any kind before treatment is initiated.
- Note that drug-induced nausea, unpleasant aftertaste and smell, dry mouth, and furry tongue may be so objectionable as to
necessitate drug withdrawal. Report to physician if symptoms persist.
- Monitor I&O rates and pattern: Check with physician regarding optimum daily fluid intake. Report any change in quality or
quantity of urine or in I&O ratio.
- Observe patient for signs of electrolyte imbalance. Each 1 g of drug contains approximately 1 mEq of sodium.
Patient & Family Education
- Take this medication with a full glass of water on an empty stomach.
- Take medication around the clock, do not miss any doses, and continue taking medication until it is all gone unless otherwise
directed by physician.