The
plasma concentrations of
tiagabine may be reduced 1.5- to 3-fold by
carbamazepine.
The manufacturers recommend that
tiagabine 30 to 45 mg (in divided doses) should be given to patients taking enzyme-inducing antiepileptics such as
carbamazepine. A lower maintenance dose of 15 to 30 mg should be given to patients who are not taking enzyme-inducing drugs.