Limited evidence suggests that
carbamazepine may decrease
methylphenidate levels.
It would seem wise to monitor the response to
methylphenidate treatment carefully in patients taking
carbamazepine. Note that the manufacturer says
methylphenidate should be used with caution in patients with
epilepsy, as it can, rarely, cause an increase in seizure frequency. If seizure frequency increases,
methylphenidate should be discontinued.