CARBAMAZEPINE AND GRAPEFRUIT JUICE

Grapefruit juice increases carbamazepine levels by about 40%. A case of possible carbamazepine toxicity has been seen in a man taking carbamazepine after he started to eat grapefruit.
The manufacturers advise monitoring levels and adjusting the dose of carbama- zepine as necessary. If monitoring is not practical, or regular intake of grapefruit is not desired, it would seem prudent to avoid grapefruit or grapefruit juice.
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