Carbamazepine has caused reductions of 50% or more in
ciclosporin levels. This has occurred within 3 days of concurrent use.
Ciclosporin levels and/or effects (e.g. on
renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring and adjust the
ciclosporin dose as needed if
carbamazepine is stopped, started, or the dose altered.