A patient died after treatment with
capecitabine possibly because the concurrent use of
folic acid enhanced
capecitabine toxicity. The maximum tolerated dose of
capecitabine is decreased by
folinic acid.
The UK manufacturers say that the maximum tolerated
capecitabine dose when
C used alone in the intermittent regimen is 3000 mg/m2, but it is reduced to
2000 mg/m2 if
folinic acid 30 mg twice daily is also given. Consider the use of folate supplements as a contributory factor in the case of troublesome
capecitabine adverse effects.