Nifedipine causes a moderate rise in
serum tacrolimus levels and also appears to be kidney protective. Diltiazem and
felodipine also appear to elevate
tacrolimus levels. Nicardipine, nilvadipine and
verapamil are predicted to interact similarly.
Tacrolimus levels and/or effects (e.g. on
renal function) should be monitored as a matter of routine, but consider increasing monitoring if one of these calcium- channel blockers is started or stopped.