The bioavailability of manidipine may be increased by food and the
plasma levels of other lipophilic
calcium-channel blockers (lercanidipine, nisoldipine) may also be affected.
It has been recommended that manidipine should be given with food. Because of the potential increase in peak
plasma concentrations, the manufacturers of lercanidipine and
nisoldipine advise giving them before meals (at least 15 minutes before has been recommended).