Felodipine, gallopamil, lacidipine, lercanidipine, nicardipine and
nisoldipine cause small increases in
digoxin levels (maximum rise seen was about 30%, which was not considered clinically significant). The situation with nitrendipine is uncertain but it possibly causes only a small rise in
digoxin levels.
Serum digoxin levels are normally unchanged or increased only to a small extent by the concurrent use of
nifedipine. However, one isolated study indicated that a 45% rise could occur.
Bear this interaction in mind if patients are treated with both drugs concurrently. The possibility of a serious interaction seems small, but if undesirable bradycardia or other
symptoms of over-digitalisation occur consider taking
digoxin levels.