BUTOCONAZOLE NITRATE
| BUTOCONAZOLE NITRATE (byoo-toe-koe'na-zole) Femstat 3, Gynazole 1 Classifications: azole antifungal antibiotic; Therapeutic: antifungal; antibiotic Prototype: Fluconazole Pregnancy Category: C |
Availability
2% cream
Action
Imidazole derivative with antifungal activity. Alters fungal cell membrane permeability, permitting loss of phosphorous compounds, potassium, and other essential intracellular constituents with consequent loss of ability to replicate. Action takes place primarily on medicated infected surface tissues.
Therapeutic Effect
Has fungicidal effect as well as effectiveness against some gram-positive bacteria.
Uses
Local treatment of vulvovaginal candidiasis.
Contraindications
Pregnancy (category C). Safety in children <12 y is not established.
Cautious Use
Hypersensitivity to azole antifungals; HIV patients; diabetes mellitus; lactation.
Route & Dosage
| Vulvovaginal Candidiasis Adult: Topical 1 applicator full intravaginally h.s. for 3 d, may be extended another 3 d if needed Pregnant women: Topical 1 applicator full intravaginally h.s. for 6 d |
Administration
Topical Intravaginal- Continue treatment even during menstruation.
- Store medication at 15°–30° C (59°–86° F); avoid extreme temperature and freezing.
Adverse Effects (≥1%)
Urogenital: Vulvar or vaginal burning, vulvar itching, discharge, soreness, swelling; urinary frequency and burning. Skin: Itching of fingers. CNS: Headache.Pharmacokinetics
Absorption: Small amount absorbed systemically from intravaginal administration. Distribution: Crosses placenta in animals. Metabolism: In liver. Elimination: In both urine and feces within 4–7 d. Half-Life: 21–24 h.Nursing Implications
Assessment & Drug Effects
- Monitor for therapeutic effectiveness. Candidiasis in nonpregnant women is usually controlled in 3 d.
Patient & Family Education
- Take medication exactly as prescribed; do not increase or decrease dosage or discontinue or extend treatment period. Contact physician if symptoms (vaginal burning, discharge, or itching) persist; drug may be discontinued if acute irritation occurs.
- Patient's sexual partner should wear a condom during intercourse.
Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; 
Canadian drug name; 
Prototype drug