An isolated report describes the development of the
serotonin syndrome, with
buspirone and citalopram. The combination of
buspirone and fluoxetine can be effective, but seizures and worsening of
symptoms have been reported. Fluvoxamine may possibly reduce the effects of
buspirone.
B Thegeneralimportanceof,andreasonsfor,theseadversereactionsarenotwell
understood, but there would seem to be little reason for avoiding concurrent use. However, bear these interactions in mind when
buspirone is given with an SSRI.