In one study the maximum levels and AUC of
buspirone were increased 5-fold and 6-fold, respectively, by
erythromycin, which resulted in psychomotor impairment and an increase in adverse effects.
Monitor the outcome of concurrent use carefully, expecting to need to reduce the
buspirone dosage. The manufacturers suggest a starting dose of
buspirone 2.5 mg twice daily. Other
macrolides (such as
clarithromycin and telithromycin) may also interact, although it seems unlikely that all
macrolides will, see
macrolides.