A study found that the AUC of the active
metabolite of
bupropion was almost doubled when
bupropion was given with
valproate. An increase in
valproate levels of almost 30% was seen in one patient.
Monitor for any evidence of increased
toxicity (due to the raised
bupropion metabolites or valproate). Note that
bupropion is contraindicated in patients with
epilepsy.