Bupropion may reduce the
metabolism of
dextromethorphan in some patients.
Dextromethorphan is generally considered to have a wide therapeutic range and its dose is not individually titrated; therefore, the interaction with
bupropion is unlikely to be clinically relevant. Nevertheless, it is possible that some patients might become more sensitive to the adverse effects of
dextromethorphan while taking
bupropion. Note that
dextromethorphan is widely found in non-prescrip- tion preparations such as cough suppressants.