BUPROPION AND CLOPIDOGREL

Clopidogrel increases the AUC of bupropion by 60% and decreases the AUC of its active metabolite, hydroxybupropion, by about 50%.
Dose adjustments may be needed. It would seem prudent to monitor for increased bupropion adverse effects (lightheadedness, gastrointestinal effects) and efficacy.
(34)
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