BUDESONIDE (bu-des'o-nide)
Entocort EC, Pulmicort Flexhaler, Rhinocort, Rhinocort Aqua, Rhinocort Turbuhaler Classifications: antiinflammatory; adrenal corticosteroid; glucocorticoid; Therapeutic: antiinflammatory; adrenal corticosteroid Prototype: Hydrocortisone Pregnancy Category: B for inhaled; C for oral
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Availability
32 mcg/inhalation; 3 mg capsule
Action
Has potent glucocorticoid activity. Its antiinflammatory action on nasal mucosa is thought to be a result of decreased IgE
synthesis and decreased arachidonic acid metabolism.
Therapeutic Effect
Glucocorticoids have a wide range of inhibitory activities against multiple cell types (e.g., neutrophils, macrophages)
and mediators (e.g., histamine, cytokines) involved in allergic and nonallergic/irritant-mediated inflammation.
Uses
Treatment of allergic and perennial rhinitis, maintain remission in mild to moderate Crohn's disease; prophylaxis for asthma.
Contraindications
Hypersensitivity to budesonide, status asthmaticus, acute bronchospasms; peptic ulcer disease; pregnancy (category C for
oral; category B for inhaled), lactation.
Cautious Use
Concomitant administration of systemic oral steroids; active or quiescent tuberculosis; infections of respiratory tract;
in sun-treated fungal, bacterial, or systemic viral infections or ocular herpes simplex; recent nasal septal ulcers; recurrent
epistaxis; nasal surgery or trauma; psychosis; myasthenia gravis; diabetes mellitus; seizure disorders.
Route & Dosage
Crohn's Disease Adult: PO 9 mg once/d in a.m. for up to 8 wk, may taper to 6 mg q.d. for 2 wk prior to discontinuing. May repeat 8-wk course for recurring
episodes of active Crohn's disease.
Asthma Prophylaxis, Rhinitis See Appendix A-3.
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Administration
Oral
- Ensure that capsules are swallowed whole and not chewed.
- Give only in the morning.
- Patients with moderate to severe liver disease should be monitored for increased signs and/or symptoms of hypercorticism.
Reducing the dose of Entocort EC capsules should be considered in these patients.
- Store at 25° C (77° F); excursions permitted to 15°30° C (59°86° F).
Adverse Effects (≥1%)
Body as a Whole: Arthralgia,
fatigue, fever, hyperkinesis, myalgia, asthenia,
paresthesia, tremor.
CNS: Dizziness, emotional lability, facial edema, nervousness,
headache, agitation, confusion,
insomnia, drowsiness.
CV: Chest pain, hypertension, palpitations, sinus tachycardia.
GI: Abdominal pain, dyspepsia, gastroenteritis, oral
candidiasis, xerostomia,
diarrhea, nausea, vomiting, cramps.
Hematologic: Epistaxis.
Metabolic: Hypokalemia, weight gain.
Respiratory: Bronchospasms,
infections, cough, rhinitis,
sinusitis,
dyspnea, hoarseness, wheezing.
Skin: Eczema, pruritus, purpura, rash,
alopecia.
Special Senses: Contact dermatitis, reduced sense of smell, nasal pain.
Urogenital: Intermenstrual bleeding, dysuria.
Interactions
Drug: Ketoconazole may increase oral budesonide concentrations and
toxicity;
toxicity may also occur with
anastrozole (high doses only),
clarithromycin, cyclosporine, danazol, delavirdine, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, indinavir, isoniazid, INH, itraconazole, mibefradil, nefazodone, nelfinavir, nicardipine, norfloxacin, oxiconazole, quinidine, quinine, ritonavir, saquinavir, troleandomycin, verapamil, and zafirlukast. Food: Grapefruit juice will significantly increase bioavailability of oral budesonide.
Pharmacokinetics
Absorption: 20% (nasal) dose, 613% of (orally inhaled) dose, 9% PO dose reaches systemic circulation; PO form is absorbed
from duodenum at pH >5.5; oral bioavailability increases 2.5 times in
hepatic cirrhosis.
Onset: 812 h inhaled, 2 wk oral.
Peak: 2 wk inhaled, 8 wk oral delayed by high-fat meal.
Distribution: 90% protein bound.
Metabolism: 85% of absorbed dose undergoes first pass
metabolism by CYP3A4.
Elimination: 60% in urine, 40% in feces.
Half-Life: 23.6 h.
Nursing Implications
Assessment & Drug Effects
- Monitor closely for S&S of hypercorticism if concomitant doses of ketoconazole or other CYP3A4 inhibitors (see Drug Interactions)
are being given.
- Monitor patients with moderate to severe liver disease for increased S&S of hypercorticism.
- Lab tests: Periodic serum potassium.
Patient & Family Education
- Notify the physician immediately for any of the following: itching, skin rash, fever, swelling of face and neck, difficulty
breathing, or if you develop S&S of infection.
- Do not drink grapefruit juice or eat grapefruit regularly.
- Avoid people with infections, especially those with chickenpox or measles if you have never had these conditions.