Classifications: antineoplastic; antiandrogen; Therapeutic: antineoplastic; antiandrogen
Pregnancy Category: X
50 mg tablets
Bicalutamide is a nonsteroidal antiandrogen. It inhibits the pharmacologic effects of androgen by binding to the androgen
receptors in the target tissue.
Prostatic carcinoma is androgen sensitive; it responds to removal of the source of androgen or treatment that counteracts
the effects of androgen.
In combination with a luteinizing hormone-releasing hormone (LHRH) analog for advanced prostate cancer.
Hypersensitivity to bicalutamide, pregnancy (category X), hepatic failure; lactation.
Moderate to severe hepatic impairment. Safety and efficacy in children are not established.
Route & Dosage
|Advanced Prostate Cancer
Adult: PO 50 mg once/d
- Give drug at the same time each day.
- Start treatment with bicalutamide at the same time as treatment with a luteinizing hormone-releasing hormone (LHRH) analog.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)CNS:
, anxiety, decreased libido, confusion, neuropathy
, somnolence, nervousness, headache. CV: Hot flashes,
hypertension, chest pain, CHF. GI: Constipation, nausea, diarrhea,
vomiting, increased liver function tests, abdominal pain, anorexia, dyspepsia, dry mouth, melena. Urogenital:
Nocturia, hematuria, UTI, impotence, gynecomastia, incontinence, frequency, dysuria, urinary retention, urgency. Metabolic:
Peripheral edema, hyperglycemia, weight loss, weight gain, gout
, myalgia, leg cramps, pathologic fractures. Skin:
Rash, sweating, dry skin, pruritus, alopecia
. Body as a Whole:
, bone pain, infection
May increase effects of oral anticoagulants
Readily from GI tract. Metabolism:
In liver. Elimination:
In urine and feces. Half-Life:
Assessment & Drug Effects
- Monitor for S&S of disease progression.
- Lab tests: Periodic PSA levels, CBC, liver functions, renal functions; with concurrent Coumadin therapy, closely monitor
PT and INR.
Patient & Family Education
- Report jaundice or any other troubling adverse effects immediately.