Rifampicin increases the loss of bisoprolol,
carvedilol, celiprolol, metoprolol, propranolol, tertatolol and talinolol from the body, and reduces their
serum levels. The extent to which this reduces the effects of these
beta blockers is uncertain, but it is probably small. However, one patient taking
atenolol experienced a reduction in exercise tolerance when given
rifampicin.
The significance of this interaction is unclear, but bear it in mind in case of an
unexpected response to treatment.