The antihypertensive effects of
beta blockers may be reduced by
NSAIDs. In some cases
this interaction has resulted in large changes in blood pressure, although the effect varies with different beta blocker/NSAID combinations. The most significant increases (of 8 to 10 mmHg) appear to be caused by indometacin.
Only some patients are affected. Monitor blood pressure if an
NSAID is started or stopped.