Cimetidine affects the
pharmacokinetics of some
beta blockers. The AUC of oral labetalol is increased by 66%, metoprolol peak
plasma levels are increased by 70%, the AUC of nebivolol is increased by 48%, the AUC of
pindolol is increased by about 40%, and the AUC of propranolol is increased by 47%. However, this only rarely appears to result in clinically significant effects.
Monitor the outcome of concurrent use, adjusting the dose of the beta blocker if necessary. Note that other
H2-receptor antagonists (e.g.
famotidine,
nizatidine and ranitidine) do not appear to interact and so may be suitable alternatives.