The combined use of
flecainide and
beta blockers may have additive cardiac depressant effects. A study on cardiac function and drug clearance found that when propranolol was given with
flecainide the AUCs of both drugs were increased by 20 to 30%, and they had some additive negative inotropic effects. An isolated case of bradycardia and fatal AV block has been reported during the use of
flecainide with
sotalol, and bradycardia has been reported in a patient taking
flecainide and timolol eye drops.
Careful monitoring has been recommended if
beta blockers are given with other antiarrhythmics. Monitor for bradycardia.