BETA BLOCKERS AND ERGOT DERIVATIVES

The use of ergot derivatives (e.g. ergotamine) with beta blockers is normally safe and beneficial, but cases of peripheral vasoconstriction have been reported following concurrent use.
This interaction is unlikely to be of general significance, but it may be prudent to be extra alert for any signs of an adverse response, particularly those suggestive of reduced peripheral circulation (coldness, numbness or tingling of the hands and feet).