BENZODIAZEPINES AND PROBENECID

Probenecid reduces the clearance of adinazolam, lorazepam and nitrazepam. Increased therapeutic and adverse effects (sedation) may be expected. There seems to be no direct information about other benzodiazepines, but those that are metabolised like lorazepam and nitrazepam (e.g. oxazepam) may also interact.
Monitor the outcome of concurrent use for increased sedation and decrease the benzodiazepine dose if this becomes troublesome. Limited evidence suggests that
temazepam does not interact.
(22)
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