The manufacturer notes that there was no clinically relevant pharmacokinetic interaction between
pregabalin and
lorazepam, and that concurrent use caused no clinically important effect on respiration. However, they note that
pregabalin may potentiate the effects of
lorazepam (presumably sedation). All
benzodiazepines seem likely to increase sedation when given with
pregabalin.
The degree of impairment will depend on the individual patient. However, warn all patients of the potential effects, and counsel against driving or undertaking other skilled tasks.