BENZODIAZEPINES AND MIRTAZAPINE

Additive adverse effects on psychomotor skills and sedation have been reported with diazepam and mirtazapine.
Patients should be warned that the sedative effects of benzodiazepines in general may be potentiated by concurrent use with mirtazapine. Note that the US manufacturer actually recommends that patients taking mirtazapine avoid the use of diazepam and similar drugs, but this is probably overly cautious.
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