The bioavailability of oral
midazolam was increased by 50% by
echinacea in one study although another study found no effects. In contrast, the clearance of
intravenous midazolam appears to be increased by
echinacea.
The
clinical importance of this interaction is uncertain. Bear it in mind if
intravenous midazolam effects are reduced, or oral
midazolam effects are increased.