BENZODIAZEPINES AND HERBAL MEDICINES OR DIETARY SUPPLEMENTS - ECHINACEA

The bioavailability of oral midazolam was increased by 50% by echinacea in one study although another study found no effects. In contrast, the clearance of intravenous midazolam appears to be increased by echinacea.
The clinical importance of this interaction is uncertain. Bear it in mind if intravenous midazolam effects are reduced, or oral midazolam effects are increased.
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