An isolated and unconfirmed report describes
temazepam toxicity, possibly due to
disulfiram. The
serum levels of chlordiazepoxide and
diazepam are increased by the use of
disulfiram and some patients may possibly experience increased drowsiness.
If sedation occurs reduce the dosage of the benzodiazepine if necessary. Other
benzodiazepines that are metabolised similarly may possibly interact in the same way (e.g. bromazepam, clobazam,
clonazepam, clorazepate, flurazepam, ketazo- lam, medazepam, nitrazepam, prazepam) but this needs confirmation. Alprazo- lam,
lorazepam and
oxazepam appear to be non-interacting alternatives.