Carbamazepine reduces the levels of
clobazam and increases the levels of its principal
metabolite. A case report describes a small rise in
carbamazepine levels resulting in
toxicity in a patient also taking clobazam, whereas a small study suggested that
clobazam increased the
metabolism of
carbamazepine.
The
clinical significance of these findings is unknown. The changes in
clobazam levels are not expected to be clinically significant.